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zadetkov: 80
21.
  • Network-based predictions o... Network-based predictions of in vivo cardiac hypertrophy
    Frank, Deborah U; Sutcliffe, Matthew D; Saucerman, Jeffrey J Journal of molecular and cellular cardiology, August 2018, 2018-08-00, 20180801, 2018-07-17, 20180800, Letnik: 121
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    Cardiac hypertrophy is a common response of cardiac myocytes to stress and a predictor of heart failure. While in vitro cell culture studies have identified numerous molecular mechanisms driving ...
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22.
  • FAK Forms a Complex with ME... FAK Forms a Complex with MEF2 to Couple Biomechanical Signaling to Transcription in Cardiomyocytes
    Cardoso, Alisson Campos; Pereira, Ana Helena Macedo; Ambrosio, Andre Luis Berteli ... Structure (London), 08/2016, Letnik: 24, Številka: 8
    Journal Article
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    Focal adhesion kinase (FAK) has emerged as a mediator of mechanotransduction in cardiomyocytes, regulating gene expression during hypertrophic remodeling. However, how FAK signaling is relayed onward ...
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23.
  • Gαq signalling: The new and... Gαq signalling: The new and the old
    Sánchez-Fernández, Guzmán; Cabezudo, Sofía; García-Hoz, Carlota ... Cellular signalling, 20/May , Letnik: 26, Številka: 5
    Journal Article
    Recenzirano

    In the last few years the interactome of Gαq has expanded considerably, contributing to improve our understanding of the cellular and physiological events controlled by this G alpha subunit. The ...
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24.
  • Network Reconstruction and ... Network Reconstruction and Systems Analysis of Cardiac Myocyte Hypertrophy Signaling
    Ryall, Karen A; Holland, David O; Delaney, Kyle A ... The Journal of biological chemistry, 12/2012, Letnik: 287, Številka: 50
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    Cardiac hypertrophy is managed by a dense web of signaling pathways with many pathways influencing myocyte growth. A quantitative understanding of the contributions of individual pathways and their ...
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25.
  • Vangl2 is essential for myo... Vangl2 is essential for myocardial remodeling activated by Wnt/JNK signaling
    Zhang, Peng; Hu, Chunxiao; Li, Yongyong ... Experimental cell research, 04/2018, Letnik: 365, Številka: 1
    Journal Article
    Recenzirano

    The Wnt/JNK pathway, responsible for tissue polarity in cardiogenesis in vertebrates, has been shown to play numerous roles during differentiation and development of cardiac myocytes. Van Gogh-like-2 ...
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26.
  • STRESS signaling pathways t... STRESS signaling pathways that modulate cardiac myocyte apoptosis
    Baines, Christopher P; Molkentin, Jeffery D Journal of molecular and cellular cardiology, 2005, 2005-Jan, 2005-01-00, 20050101, Letnik: 38, Številka: 1
    Journal Article
    Recenzirano

    The heart is a dynamic organ capable of significant architectural remodeling, cellular adaptations, and molecular reprogramming following both physiologic and pathologic stimulation. These whole ...
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27.
  • Isoform-Specific Regulation... Isoform-Specific Regulation of the Actin-Organizing Protein Palladin during TGF-β1-Induced Myofibroblast Differentiation
    Rönty, Mikko J; Leivonen, Suvi-Katri; Hinz, Boris ... Journal of investigative dermatology, November 2006, 2006, 2006-11-00, 2010-03-25, Letnik: 126, Številka: 11
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    Contractile myofibroblasts are responsible for remodeling of extracellular matrix during wound healing; however, their continued activity results in various fibrocontractive diseases. Conversion of ...
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28.
  • Ageing alters the severity ... Ageing alters the severity of Sunitinib-induced cardiotoxicity: Investigating the mitogen activated kinase kinase 7 pathway association
    Cooper, Samantha; Sandhu, Hardip; Hussain, Afthab ... Toxicology (Amsterdam), 01/2019, Letnik: 411
    Journal Article
    Recenzirano

    Anti-cancer drug Sunitinib is linked to adverse cardiovascular events, which have shown to involve mitogen activated kinase kinase 7 (MKK7) pathway. Sunitinib-induced cardiotoxicity in 3, 12 and 24 ...
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29.
  • Involvement of mitogen acti... Involvement of mitogen activated kinase kinase 7 intracellular signalling pathway in Sunitinib-induced cardiotoxicity
    Cooper, Samantha Louise; Sandhu, Hardip; Hussain, Afthab ... Toxicology (Amsterdam), 02/2018, Letnik: 394
    Journal Article
    Recenzirano

    The tyrosine kinase inhibitor Sunitinib is used to treat cancer and is linked to severe adverse cardiovascular events. Mitogen activated kinase kinase 7 (MKK7) is involved in the development of ...
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30.
  • EMMPRIN activates multiple ... EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-κB andMKK7/JNK/AP-1 signaling
    Venkatesan, Balachandar; Valente, Anthony J; Prabhu, Sumanth D ... Journal of molecular and cellular cardiology, 2010, 2010-10-00, Letnik: 49, Številka: 4
    Journal Article
    Recenzirano

    Abstract The transmembrane glycoprotein extracellular matrix metalloproteinase inducer (EMMPRIN), and the pleiotropic proinflammatory cytokine interleukin (IL)-18, play critical roles in myocardial ...
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